![]() Optimally, any available increases to a particular stat should be taken before taking the item that lowers it.Stat penalties are accounted for, causing increased difficulty of reaching new best values.Temporary positive multipliers are not retained, only the values reached through them are.Stacking as many temporary buffs at once as possible may be helpful to reach particularly high values.For example, using The Book of Belial to gain +2 damage will stay in effect indefinitely, but while it's not currently activated, Isaac must earn more than +2 damage from other items to see a difference.Temporary buffs work normally, though they may make reaching new best values harder after the buff has worn off.Health downs do not count as stat downgrades for Rock Bottom. ![]()
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